Liberation of antidiuretic hormone: location of ascending pathways

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Abstract
Water diuresis was established and maintained in dogs anesthetized with chloralose. Both ureters were cannulated and a continuous recording of urine flow obtained. Antidiuretic responses (equivalent to 5–10 mU total dose of arginine vasopressin iv) were obtained from stimulation of the central end of a vagus or ulnar nerve and from certain reactive areas in the medulla, pons, and midbrain. In the medulla, responses were frequently obtained from the area of the tractus solitarius and from many points in the lateral reticular formation. In the pons, responses were elicited from the medial portion of the central gray and from the lateral reticular formation. The area of the medial lemniscus was not responsive. At levels rostral to the inferior colliculus, the reactive area was limited to the area of the central tegmental tract and the periaqueductal gray. The evidence suggests that impulses from the visceral and somatic afferent systems mediating ADH release ascend through the brain stem over an extralemniscal pathway. The mammillary peduncle does not appear to be part of the ascending pathway mediating ADH release; rather, impulses may reach the hypothalamus through a relay in the thalamus as well as by relay over the periventricular system of Schütz.

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