THIS REPORT concerns two white female siblings who have what we believe to be a newly recognized hereditary syndrome involving facial clefting. The designation HMC syndrome, after the prominent clinical findings ofhypertelorism,microtia andclefting, is suggested by the authors. Report of Cases Patient 1 was born in July 1956 and is now 12 years of age. Her sister, patient 2, was born in October 1960 and is now 8 years old. Both girls were originally seen in the University of Minnesota clinics for multiple congenital anomalies in 1961. Subsequently, after the parents moved, the sisters were further studied by staff members of the Department of Medical Genetics at Indiana University Medical Center. The mother and father are 42 years of age, and there is neither known consanguinity nor a family history of individuals with facial appearance even remotely resembling these girls. However, there is a