Synthesis of new pyrazolo[4,3-e]1,2,4-triazolo[1,5-c] pyrimidine and 1,2,3-triazolo[4,5-e]1,2,4-triazolo[1,5-c] pyrimidine displaying potent and selective activity as A2a adenosine receptor antagonists.
- 1 November 1994
- journal article
- Published by Elsevier in Bioorganic & Medicinal Chemistry Letters
- Vol. 4 (21) , 2539-2544
- https://doi.org/10.1016/s0960-894x(01)80279-1
Abstract
No abstract availableKeywords
This publication has 20 references indexed in Scilit:
- Effects of the new A2 adenosine receptor antagonist 8FB‐PTP, an 8 substituted pyrazolo‐triazolo‐pyrimidine, on in vitro functional modelsBritish Journal of Pharmacology, 1994
- Photoisomerization of a potent and selective adenosine A2 antagonist, (E)-1,3-dipropyl-8-(3,4-dimethoxystyryl)-7-methylxanthineJournal of Medicinal Chemistry, 1993
- Adenosine receptors and their modulatorsPharmaceutica Acta Helvetiae, 1993
- Structure-activity relationships of 8-styrylxanthines as A2-selective adenosine antagonistsJournal of Medicinal Chemistry, 1993
- Synthesis of imidazo[1,2-c]pyrazolo[4,3-e]pyrimidines, pyrazolo[4,3-e]1,2,4-triazolo[1,5-c]pyrimidines and 1,2,4-triazolo[5,1-i]purines: new potent adenosine A2 receptor antagonistsEuropean Journal of Medicinal Chemistry, 1993
- (E)-1,3-Dialkyl-7-methyl-8-(3,4,5-trimethoxystyryl)xanthines: potent and selective adenosine A2 antagonistsJournal of Medicinal Chemistry, 1992
- Adenosine receptors: pharmacology, structure-activity relationships, and therapeutic potentialJournal of Medicinal Chemistry, 1992
- RDC8 codes for an adenosine A2 receptor with physiological constitutive activityBiochemical and Biophysical Research Communications, 1990
- 4-Amino[1,2,4]triazolo[4,3-a]quinoxalines. A novel class of potent adenosine receptor antagonists and potential rapid-onset antidepressantsJournal of Medicinal Chemistry, 1990
- Structure-activity profile of a series of novel triazoloquinazoline adenosine antagonistsJournal of Medicinal Chemistry, 1988