Making DNA Add
- 12 July 1996
- journal article
- other
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 273 (5272) , 220-223
- https://doi.org/10.1126/science.273.5272.220
Abstract
Recent studies have demonstrated the feasibility of using DNA-based experiments to compute solutions to combinatorial problems. However, a prerequisite for designing a computer useful in a wide range of applications is the ability to perform mathematical calculations. The development of a DNA-based algorithm for addition is presented. The DNA representation of two nonnegative binary numbers is presented in a form permitting a chain of primer extension reactions to carry out the addition operation. To demonstrate the feasibility of this algorithm, a simple example was executed biochemically.Keywords
This publication has 3 references indexed in Scilit:
- DNA Solution of Hard Computational ProblemsScience, 1995
- Molecular Computation of Solutions to Combinatorial ProblemsScience, 1994
- Thyrotropin-Releasing Hormone Action on the Prolactin Promoter Is Mediated by the POU Protein Pit-1Molecular Endocrinology, 1991