A nitroimidazole-thiadiazole derivative with curative action in experimentalTrypanosoma cruziinfections

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Abstract
A nitroimidazole-thiadiazole derivative [(2-amino-5-(1-methyl-5-nitro-2-imidazolyl)-1,3,4- thiadiazole)] displays a marked curative effect in mice experimentally infected with Trypanosoma cruzi. When doses of 50 or 100 mg kg−1 were used for 20 consecutive days, parasitological cures (assessed by fresh blood examination, haemoculture, sub-inoculation, re-inoculation and indirect immunofluorescent test) were obtained in 100% of the animals. High curative levels were also observed with a single dose (500 mg kg−1) of this drug. Such cure rates were not observed when similar treatment schedules were used with standard and- T. cruzi drugs such as 5-nitrofuran and 2-nitroimidazoIe derivatives, including those already being used clinically.

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