The FMRFamide-like neuropeptide AF2 is present in the parasitic nematode Haemonchus contortus
- 1 January 1995
- journal article
- research article
- Published by Cambridge University Press (CUP) in Parasitology
- Vol. 111 (4) , 515-521
- https://doi.org/10.1017/s0031182000066026
Abstract
SUMMARY: Peptides belonging to the FMRFamide family are widely distributed amongst invertebrates. We report here on the isolation of the FMRFamide neuropeptide AF2 (Lys-His-Glu-Tyr-Leu-Arg-Phe-NH2) from the parasitic nematode Haemonchus contortus. Immunocytochemical techniques showed that FMRFamide-like material was distributed in several regions of these organisms including nerve cords and cell bodies of the central nervous system. AF2 was isolated using a method that employed 6 steps of reverse-phase HPLC. The concentration of AF2 in this organism was approximately 30 pmol/g of nematode.Keywords
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