Palladium-Catalyzed Multicomponent Coupling of Alkynes, Imines, and Acid Chlorides: A Direct and Modular Approach to Pyrrole Synthesis
- 23 December 2003
- journal article
- Published by American Chemical Society (ACS) in Journal of the American Chemical Society
- Vol. 126 (2) , 468-469
- https://doi.org/10.1021/ja039152v
Abstract
A new palladium-catalyzed method to prepare pyrroles directly from three basic building blocksimines, alkynes, and acid chloridesis described. This approach provides a straightforward method both to prepare pyrroles in one step and to diversify their structure by simple variation of any of the three starting materials. Mechanistic studies suggest that this process occurs via a complex series of eight individual steps, and this is discussed.Keywords
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