The Reaction of Articular Cartilage to Injury and Osteoarthritis

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Abstract
THE principal purpose of this review is to outline the state of knowledge of the response of articular cartilage to trauma and to attempt to relate the data to osteoarthritic disease. In consideration of this subject, it seems important to define the biologic characteristics of normal articular cartilage and then to indicate the nature of the response of this tissue to injury.Normal Articular CartilageThe hyaline cartilages covering the articulating ends of the component bones of diarthrodial joints are composed of a highly specialized form of connective tissue, with biochemical and biophysical characteristics well suited to its dual role . . .