Plasma Concentration of Lidocaine after Endotracheal Spray

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Abstract
The rate of absorption and plasma concentrations of lidocaine were determined in 15 supine patients under general anesthesia following either endotracheal spray of 200 mg. (average 3.3 mg./kg.) of 4 percent lidocaine hydrochloride solution with a special cannula (LTA® Kit, Abbott) (N = 6) or 1 mg./kg. of 2 percent lidocaine solution as an intravenous bolus injection (N = 9). In the 6 patients after endotracheal spray, peak plasma lidocaine levels were reached at 15 to 20 minutes (mean 3.54 ± 0.76 S.E.μg./ml. at 20 minutes). In the 9 patients given 1 mg./kg. intravenously, dose peak concentrations were reached within 2 minutes (mean 5.63 ± 0.18 S.E.μg./ml. at 2 minutes). Plasma concentrations of lidocaine in both groups were within nontoxic ranges.

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