Similarity of the Carbohydrate Structures of H-2 and Ia Glycoproteins
Open Access
- 1 August 1977
- journal article
- research article
- Published by Oxford University Press (OUP) in The Journal of Immunology
- Vol. 119 (2) , 477-482
- https://doi.org/10.4049/jimmunol.119.2.477
Abstract
The glycopeptides produced by pronase digestion of two H-2K, two H-2D, and three Ia glycoprotein antigens were examined for size and charge. The glycopeptides derived from all of the antigens examined were found to have m.w. of 3250 ± 200 daltons with a similar and variable composition of sialic acid residues. These data, when combined with the similarity in monosaccharide incorporation, suggest that the general parameters of the carbohydrate structure of the Ia glycoproteins from different I subregions and H-2 glycoproteins are highly similar if not identical.This publication has 4 references indexed in Scilit:
- Low-molecular-weight Ia antigens in normal mouse serumImmunogenetics, 1976
- Properties of the antigen-specific suppressive T-cell factor in the regulation of antibody response of the mouse. IV. Special subregion assignment of the gene(s) that codes for the suppressive T-cell factor in the H-2 histocompatibility complex.The Journal of Experimental Medicine, 1976
- A new I subregion (I-J) marked by a locus (Ia-4) controlling surface determinants on suppressor T lymphocytes.The Journal of Experimental Medicine, 1976
- Regulatory Variants for the Expression of H-2 Antigens. I. Isolation and Characterization2JNCI Journal of the National Cancer Institute, 1976