Heat Stability Studies of Clotting Factors in "Thromboplastic" Preparations

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Abstract
On the basis of heat stability studies, the clotting properties of rabbit brain tissues were found to be due to 2 different components: (1) a thrombokinase, which has the capacity to convert prothrombin directly to thrombin, and (2) a thromboplastin, which is an accessory factor and must react first with another plasma factor (proconvertin) before it is capable of converting prothrombin to thrombin. The indirect effect of thromboplastin must be distinguished from the direct action of thrombokinase on prothrombin if the mode of action of so-called thromboplastic brain tissue extracts is to be understood.