Heat mutagenesis in bacteriophage T4: the transversion pathway.
- 1 November 1976
- journal article
- research article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 73 (11) , 4159-4163
- https://doi.org/10.1073/pnas.73.11.4159
Abstract
Heat induces transversions (and transitions) at G.cntdot.C base pairs in bacteriophage T4. The target base for transversions in guanine, which is converted to a product which is sometimes replicated and transcribed as a pyrimidine. A model for this process is proposed in which the deoxyguanosine glycosidic bond migrates from N9 to N2: the resulting deoxyneoguanosine may pair with normal guanine to produce G.cntdot.C .fwdarw. C.cntdot.G transversions.This publication has 25 references indexed in Scilit:
- Transversion mutagenesis in bacteriophage T4Molecular Genetics and Genomics, 1975
- Kinetics and mechanism of the acid-catalyzed hydrolysis of some purine nucleosidesJournal of the American Chemical Society, 1970
- Spontaneous mutations accumulating in bacteriophage T4 in the complete absence of DNA replication.Proceedings of the National Academy of Sciences, 1966
- neo-Guanylic acid produced by the action of acid on ribonucleic acidBiochimica et Biophysica Acta (BBA) - Specialized Section on Nucleic Acids and Related Subjects, 1964
- A CHANGE FROM NONSENSE TO SENSE IN THE GENETIC CODEProceedings of the National Academy of Sciences, 1962
- REVERSAL OF MUTANT PHENOTYPES BY 5-FLUOROURACID: AN APPROACH TO NUCLEOTIDE SEQUENCES IN MESSENGER-RNAProceedings of the National Academy of Sciences, 1962
- Studies on depurination of DNA by heatJournal of Molecular Biology, 1962
- Mutagenesis of bacteriophage T4 by acridinesJournal of Molecular Biology, 1961
- EFFECTS OF HEATING DRY BACTERIA AND SPORES ON THEIR PHENOTYPE AND GENOTYPEProceedings of the National Academy of Sciences, 1960
- On the molecular explanation of spontaneous and induced mutations.1959