Effects of Diuretics on Calcium Excretion and Ca2+-Activated ATPase in Rat Kidney
Open Access
- 1 January 1977
- journal article
- research article
- Published by Elsevier in The Japanese Journal of Pharmacology
- Vol. 27 (2) , 205-211
- https://doi.org/10.1254/jjp.27.205
Abstract
Effects of 3 diuretics on the urinary Ca2+ excretion and on the microsomal Ca2+-activated ATPase were examined in the rat kidney. Furosemide and bumetanide increased Na+, K+ and Ca2+ excretion in the rats. Acetazolamide increased Na+ and K+ excretion but not Ca2+. Urinary Pi excretion was not affected during the administration of acetazolamide. Acetazolamide appears to inhibit Na+ transport without affecting Ca2+ reabsorption in the rat nephron. Microsomal ATPase of the rat kidney cortex was stimulated by Ca2+ or Mg2+ alone and an additive effect of the 2 cations was not observed. Microsomal ATPase activated by Ca2+ or Mg2+ was not inhibited by furosemide, bumetanide and acetazolamide. The inhibitory effect of furosemide and bumetanide on the Ca2+ reabsorption is probably not related to the inhibition of Ca2+-activated ATPase.This publication has 0 references indexed in Scilit: