HIGH-DOSE ALPHA-TOCOPHEROL AS A PREVENTIVE OF DOXORUBICIN-INDUCED ALOPECIA

  • 1 October 1986
    • journal article
    • research article
    • Vol. 70  (10) , 1213-1214
Abstract
The effectiveness of alpha-tocopherol acetate as a preventive of doxorubicin-induced alopecia was evaluated in 20 patients with different types of solid tumors. All received therapy containing doxorubicin in a dose range of 50-60 mg/m2/cycle of treatment. The observed hair loss was severe in 90% and moderate in 10% of the patients. No protective activity of alpha-tocopherol was demonstrated in this trial.