Familial pericentric inversion 19.

Abstract
Several members in 2 families had a pericentric inversion of chromosome 19. A review of 4 previous cases, together with those reported here, suggests that inversion of chromosome 19 is not related to the phenotypic features of the probands. There has been no report of an affected subject resulting from a duplication deficiency product of inverted chromosome 19 among the offspring of inversion heterozygotes. The suggested association of aneuploidy in the inversion carriers is also discussed.