Lack of Withdrawal Signs of Dependence following Cessation of Treatment or Ro-15,1788 Administration to Rats Chronically Treated with Buspirone

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Abstract
Failure to gain weight during withdrawal from chronic regimens of dependence-producing drugs is observed in laboratory rats. Withdrawal from the benzodiazepine anxiolytic agent diazepam, whether induced by cessation of treatment or precipitated by administration of the specific benzodiazepine antagonist Ro-15,1788, is accompanied by weight loss. However, the same withdrawal treatments following a chronic regimen of equal doses of the nonbenzodiazepine antianxiety drug buspirone are not associated with weight loss. Buspirone-treated rats gain weight during withdrawal, suggesting that this noval anxiolytic should lack dependence liability in man.

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