Leydig Cell Desensitization by Increased Cyclic-AMP Inactivation
- 1 January 1979
- journal article
- research article
- Published by Taylor & Francis in Archives of Andrology
- Vol. 2 (1) , 89-91
- https://doi.org/10.3109/01485017908987298
Abstract
Exposure of rat Leydig cells to high doses of LH/hCG in vivo results in a dose-dependent and temporary desensitization of the androgenic and cAMP response to LH/hCG when tested in vitro [l, 21. The same high doses of LH/hCG reduce the concentration of LH/hCG receptors on testicular membrane particles [3-51. Such decrease in the concentration of LH/hCG receptors may reduce sensitivity to LH/hCG [1, 23. The present paper provides indirect evidence for an additional mechanism by which LH/hCG may cause Leydig cell desensitization by either directly or indirectly stimulating the intracellular levels of phosphodiesterase (PDE) and thus reducing the magnitude of the cAMP response.Keywords
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- Gonadotropin-induced regulation of luteinizing hormone receptors and desensitization of testicular 3':5'-cyclic AMP and testosterone responses.Proceedings of the National Academy of Sciences, 1977
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- Effect of LH on Steroidogenesis and Cyclic AMP Accumulation in Rat Leydig Cell Preparations and Mouse Tumor Leydig CellsEndocrinology, 1973