From DNA sequence to biological function
- 1 February 1996
- journal article
- Published by Springer Nature in Nature
- Vol. 379 (6566) , 597-600
- https://doi.org/10.1038/379597a0
Abstract
Genome sequencing is leading to the discovery of new genes at a rate 50-100 times greater than that achieved by classical genetics, but the biological function of almost half of these genes is completely unknown. In order fully to exploit genome sequence data, a systematic approach to the discovery of gene function is required. Possible strategies are discussed here in the context of functional analysis in the yeast Saccharomyces cerevisiae, a model eukaryote whose genome sequence will soon be completed.Keywords
This publication has 50 references indexed in Scilit:
- Rice genome analysis by integration of sequencing and mapping dataJournal of Biotechnology, 1995
- Whole-Genome Random Sequencing and Assembly of Haemophilus influenzae RdScience, 1995
- The Bacillus subtilis genome project: Aims and progressTrends in Biotechnology, 1995
- Complete Nucleotide Sequence of Saccharomyces cerevisiae Chromosome VIIIScience, 1994
- Complete DNA sequence of yeast chromosome XINature, 1994
- 2.2 Mb of contiguous nucleotide sequence from chromosome III of C. elegansNature, 1994
- The human genome project.Proceedings of the National Academy of Sciences, 1993
- Genes and genomes: Towards construction of an overlapping YAC library of theArabidopsis thaliana genomeBioEssays, 1993
- The complete DNA sequence of yeast chromosome IIINature, 1992
- The C. elegans genome sequencing project: a beginningNature, 1992