Nutritional Vitamin B12Deficiency in Infancy: Three Case Reports and a Review of the Literature
- 1 January 1989
- journal article
- review article
- Published by Taylor & Francis in Pediatric Hematology and Oncology
- Vol. 6 (2) , 161-172
- https://doi.org/10.3109/08880018909034282
Abstract
Three cases of vitamin B12 deficiency that occurred during infancy are presented. These cases appeared to be the result of pre-existing maternal deficiency. All three infants demonstrated evidence of neurodevelopmental delay at presentation, and one had sustained loss of milestones and developed involuntary motor movements. Prior to the initiation of therapy, all three infants were anemic: one was thrombocytopenic and one pancytopenic. In all three cases the hematologic and neurologic abnormalities were corrected with vitamin B12 therapy. The literature is reviewed and discussed with respect to the mechanism of the infants' vitamin B12 deficiency and neurodevelopmental manifestations.Keywords
This publication has 23 references indexed in Scilit:
- Developmental Regression as an Early Manifestation of Vitamin B12 DeficiencyClinical Pediatrics, 1986
- Vitamin D Deficiency Rickets and Vitamin B12 Deficiency in Vegetarian ChildrenActa Paediatrica, 1985
- FALSE LOW SERUM VITAMIN B12 VALUES WITH RADIODILUTION ASSAYS USING BLOCKED R-BINDERSThe Lancet, 1983
- Vitamin B12 deficiency in an infant strictly breast-fed by a mother with latent pernicious anemiaThe Journal of Pediatrics, 1982
- A Syndrome of Methylmalonic Aciduria, Homocystinuria, Megaloblastic Anemia and Neurologic Abnormalities in a Vitamin B12-Deficient Breast-Fed Infant of a Strict VegetarianNew England Journal of Medicine, 1978
- Maternal Milk and Serum Vitamin B12, Folic Acid, and Protein Levels in Indian SubjectsArchives of Disease in Childhood, 1970
- Nutritional vitamin B12 deficiency in an infantThe Journal of Pediatrics, 1969
- Megaloblastic Anaemia of Infancy and Vitamin B12British Journal of Haematology, 1967
- Vitamin-B12 Deficiency in Pregnancy and the PuerperiumBMJ, 1962
- Megaloblastic Anemia in Infancy: Megaloblastic Anemia Occurring in an Infant of a Mother Suffering from Pernicious Anemia of PregnancyActa Paediatrica, 1954