Further Mechanisms Determining Respiratory Waves in the Cerebrospinal Fluid Pressure

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Abstract
Possible mechanisms producing respiratory waves in the cerebrospinal fluid pressure (CSFP) were investigated in cats and rab- bits. Differences between spontaneous and hyperpneic breathing as well as artificial respiration in the pressure waves were observed. The effects of central inhibition produced by pentobarbital and peripheral respiratory arrest (curare) were found to differ. Central inhibition resulted in a total absence of respiratory waves in CSFP as well as in arterial and venous blood pressure recordings. On the other hand, neuromuscular block was followed by the delayed appearance of slower waves, in all pressures recorded. The appearance of these late waves could be correlated with the CO2 level in the arterial blood.

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