Effect of Short-Term Tolbutamide Treatment on Insulin Dynamics in Newly Diagnosed Obese and Non-Obese Adult Diabetics

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Abstract
Blood glucose and plasma insulin responses to oral glucose and I.V. tolbutamide were measured before and after 2-month oral treatment with tolbutamide in 5 patients with maturity-onset diabetes. The improvement in glucose tolerance was not associated with an increase in plasma insulin, but with a decrease in its output, after I.V. tolbutamide, in the non-obese and no change in the obese, probably related to the maintenance of obesity and the insulin antagonism associated with it.

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