Amplification of Responses to Sumatriptan by Various Agonists in Rabbit Isolated Iliac Artery
- 1 March 1995
- journal article
- Published by Wolters Kluwer Health in Journal of Cardiovascular Pharmacology
- Vol. 25 (3) , 508-10
- https://doi.org/10.1097/00005344-199503000-00025
Abstract
Rabbit iliac arteries (IA) were almost unresponsive to the serotonin (5-HT1-like) receptor agonist sumatriptan under control conditions, whereas this agent elicited concentration-dependent contractions in IA rings given a moderate tone by threshold concentrations (EC10-EC20) of prostaglandin F2 alpha (PGF2 alpha), angiotensin II (AII), histamine, norepinephrine (NE), phenylephrine (PE), or potassium chloride. These results suggest that 5-HT1-like receptors are uncovered not only by histamine or thromboxane/prostaglandin receptor agonists, as shown in rabbit renal and femoral arteries, but also by various agonists in rabbit IA as shown in this study.Keywords
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