Boron-loaded macromolecules in experimental physiology: tracing by neutron capture radiography

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Abstract
The search for suitable methods of attaching the boron isotope 10B to tumor cells in the human body for the treatment of malignat disease has prompted a study of ways of optimizing the localization of 10B in mammalian tissues. Compounds rich in boron, linked to various carriers, were studied in experimental animals and in systems of cultivated cells. The current experimental prerequisites and results are outlined. The method for neutron capture radiography has significant potential for general application in experimental physiology. The techniques are presented from this viewpoint and compared with other methods for visualization of macromolecular markers by the use of physical or chemical principles.