Enhancement of 12-O-Tetradecanoylphorbol-13-acetate-induced Tumor Necrosis Factor .ALPHA. Production by Phenethylphthalimide Analogs.
- 1 January 1994
- journal article
- Published by Pharmaceutical Society of Japan in Biological & Pharmaceutical Bulletin
- Vol. 17 (9) , 1313-1315
- https://doi.org/10.1248/bpb.17.1313
Abstract
Effects of phenyl-, benzyl-, phenethyl-, and phenylpropylphthalimides on 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced tumor necrosis factor (TNF)-alpha production by human leukemia cell line HL-60 were examined. Among the four phthalimide derivatives, only phenethylphthalimide showed potent enhancing effect on TNF-alpha production.Keywords
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