DEMONSTRATION OF PANCREATIC PROTEASE-ANTIPROTEASE COMPLEXES IN THE PERITONEAL-FLUID OF PATIENTS WITH ACUTE-PANCREATITIS

  • 1 January 1979
    • journal article
    • research article
    • Vol. 85  (4) , 451-456
Abstract
During a 4 yr period (1972 to 1975), 69 patients with acute severe pancreatitis, of whom 58 had hemorrhagic pancreatitis, were treated with peritoneal lavage at the intensive care ward of Malmo General Hospital. The mortality rates in these 4 yr were 27%, 28%, 17%, and 14%, respectively. Peritoneal exudates were analyzed from 10 patients with hemorrhagic pancreatitis, 4 of whom died. About 65% of .alpha.2-macroglobulin was in complexed form, as was 15% of .alpha.1-antitrypsin. Immunochemical analyses of the .alpha.1-antitrypsin revealed the presence of trypsin, chymotrypsin and elastase complexed with .alpha.1-antitrypsin. This means that the pancreatic proteases were activated, as only active proteases are bound by plasma protease inhibitors.

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