METABOLIC EFFECTS OF ANABOLIC-STEROID ON SKELETAL-MUSCLE

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  • 1 January 1979
    • journal article
    • research article
    • Vol. 11  (2) , 160-163
Abstract
The effects of anabolic steroid treatment on protein synthesis in skeletal muscle and on steroid receptors was studied. The experiments were conducted with 230 male albino rats maintained on a diet containing 20% protein. Anabolic steroids (methandrostenolone, methylandrostendiole and Retabolil) were injected in doses of 0.5 mg/kg body weight. The animals were examined at rest and after swimming exercise of 15 min duration. Quadriceps and gastrocnemius muscle were used for analysis in all experiments. Protein synthesis was studied by [14C]-leucine incorporation. Anabolic steroid treatment resulted in an increased content of skeletal muscle protein: myosin, myofibrillar and sarcoplasmic fractions. The activity of RNA-polymerase in skeletal muscle nuclei was increased. In skeletal muscle there were androgen receptors which evidently were binding sites for [3H]-testosterone and anabolic steroids. A model for the anabolic steroid action on the regulation of protein synthesis in skeletal muscle was proposed.

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