Rapid Synthesis of 2' and 3' Fluorinated Nucleotides and Their Use in 19F-NMR-Spectroscopy of Nucleotide-Binding Enzymes

1 January 1989

journal article
research article
Published by Taylor & Francis in Nucleosides, Nucleotides and Nucleic Acids

Vol. 8 (5) , 1041-1042
https://doi.org/10.1080/07328318908054272

Abstract

Improved methods have been developed for the syntheses of nucleoside analogs with fluorine atoms in the furanose moiety. 5′-O-mono and triphosphates of these analogs were used in stuctural studies on adenylate kinase using ¹⁹F-NMR.

Keywords

RAPID SYNTHESIS
BINDING ENZYMES
FLUORINATED NUCLEOTIDES
NUCLEOSIDE ANALOGS
ADENYLATE KINASE
KINASE USING
USING 19F
FURANOSE MOIETY
STUCTURAL STUDIES

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