Metabotropic Glutamate Receptors and Epileptogenesis
Open Access
- 1 May 2002
- journal article
- Published by SAGE Publications in Epilepsy Currents
- Vol. 2 (3) , 81-85
- https://doi.org/10.1046/j.1535-7597.2002.00031.x
Abstract
Activation of metabotropic glutamate receptors (mGluRs) often produces long-lasting effects on the excitability of cortical neurons. For example, mGluR stimulation induces long-term potentiation or depression of excitatory synaptic transmission in the hippocampus. Similarly, the effects of mGluRs on cortical epileptiform activities also are enduring. A transient application of group I mGluR agonists to hippocampal slices produces ictal-like discharges that persist for hours after the removal of the applied agonist. This action of group I mGluRs—transforming “normal” hippocampal slice into an “epileptic-like” one—may represent a form of epileptogenesis. The advent of such a model, in which epileptogenesis can be reliably induced in an in vitro preparation and the process is complete within hours, may facilitate the exploration of cellular mechanisms underlying epileptogenesisKeywords
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