Simplified serological test for antibodies to Chlamydia trachomatis

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Abstract
Sera (360) from unselected patients attending 2 London [England] venereal disease clinics were examined by a microimmunofluorescence test. Egg-grown serotypes (11) of C. trachomatis and the fast strain SA2(f) were used as antigens. Of the 360 sera tested, 119 (33%) reacted to a titer of .gtoreq. 1:16 with at least 1 antigen. Of these positive sera, > 50% cross-reacted with all 12 serotypes, and 95.5% reacted with SA2(f) in addition to other antigenic types. SA2(f) could be used as a single antigen for preliminary screening of a large number of sera for the presence or absence of chlamydial antibody.