Molecular Epidemiology of Macrolide-Resistant Streptococcus pneumoniae Isolates in Europe
Open Access
- 1 March 2005
- journal article
- Published by American Society for Microbiology in Journal of Clinical Microbiology
- Vol. 43 (3) , 1294-1300
- https://doi.org/10.1128/jcm.43.3.1294-1300.2005
Abstract
In many European countries, the level of pneumococcal resistance to macrolides has now passed the level of resistance to penicillin G. A total of 82 erythromycin A-resistant isolates of Streptococcus pneumoniae were collected by 11 laboratories in seven European countries. All of the isolates were tested for antimicrobial susceptibility, analyzed for clonal relatedness by multilocus sequence typing, and characterized for macrolide resistance genotypes. The prevalence of the macrolide resistance genotypes varied substantially between countries. In France (87.5% of all strains), Spain (77.3%), Switzerland (80%), and Poland (100%), strains were predominantly erm (B) positive, whereas higher levels of mef (A)-positive strains were reported from Greece (100%) and Germany (33.3%). Macrolide resistance was caused by the oligoclonal spread of some multilocus sequence types, but significant differences in clonal distribution were noted between France and Spain, countries from which high levels of macrolide resistance have been reported. Overall, sequence type 81 (Spain23F-1 clone) was by far the most widespread. The mainly erm (B)-positive serotype 14 clone (sequence type 143), first reported in Poland in the mid-1990s, is now widespread in France.Keywords
This publication has 34 references indexed in Scilit:
- Clinical efficacy of ketolides in the treatment of respiratory tract infectionsJournal of Antimicrobial Chemotherapy, 2004
- Emergence of a fluoroquinolone-resistant strain of Streptococcus pneumoniae in EnglandJournal of Antimicrobial Chemotherapy, 2003
- Phenotypic and Genotypic Characterization of Two Penicillin-Susceptible Serotype 6B Streptococcus pneumoniae Clones Circulating in ItalyJournal of Clinical Microbiology, 2003
- Molecular Characterization of Erythromycin-Resistant Clinical Isolates of the Four Major Antimicrobial-Resistant Spanish Clones ofStreptococcus pneumoniae(Spain23F-1, Spain6B-2, Spain9V-3, and Spain14-5)Microbial Drug Resistance, 2003
- Identification of Multidrug-ResistantStreptococcus pneumoniaeStrains Isolated in Poland by Multilocus Sequence TypingMicrobial Drug Resistance, 2003
- Phenotypes and Genotypes of Erythromycin-Resistant Pneumococci in ItalyJournal of Clinical Microbiology, 2003
- Emergence of Macrolide Resistance during Treatment of Pneumococcal PneumoniaNew England Journal of Medicine, 2002
- Nomenclature of Major Antimicrobial-Resistant Clones of Streptococcus pneumoniae Defined by the Pneumococcal Molecular Epidemiology NetworkJournal of Clinical Microbiology, 2001
- Mechanisms of Macrolide Resistance in Clinical Pneumococcal Isolates in FranceAntimicrobial Agents and Chemotherapy, 2001
- A multilocus sequence typing scheme for Streptococcus pneumoniae: identification of clones associated with serious invasive diseaseMicrobiology, 1998