Influence of hormones and drugs on canine pancreatic blood flow

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Abstract
The K42 (and Rb86) clearance technique has been shown to provide a reasonably accurate measure of pancreatic blood flow. In anesthetized, intact control dogs, pancreatic perfusion was 0.6 mg/min.-g. This was significantly increased by secretin, nor-epinephrine, and cortisone and decreased by epinephrine and Pitressin. Pancreozymin, histamine, Dibenzyline and hypercarbia had no marked effect. Cortisone induced a significant hyperplasia of the organ.

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