The Use of Gastric Mucin to Lower Resistance of Laboratory Animals to Systemic Fungus Infections

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Abstract
Most of the deep fungi pathogenic to man produce non-lethal infections in mice. By suspending these fungi in gastric mucin, it has been possible to produce extensive intraperit. lesions and usually death. This method is suitable for chemotherapeutic studies; as a diagnostic tool in cases where only a few organisms are present in tissue; involves the use of a cheap, available laboratory animal; and affords a, rapid method of obtaining the yeast phase of dimorphic organisms. Gastric mucin gave no potentiating effect when suspensions of fungi were placed on the chorio-allantoic membrane of the chick embryo.
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