Treatment of Otitis Media With Cefaclor, a New Oral Cephalosporin

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Abstract
Cefaclor, a new semisynthetic cephalosporin, was evaluated for efficacy in the treatment of otitis media in 46 pediatric patients who had aspiration of the middle ear for culture. The dose of cefaclor ranged from 29-42 mg/kg per day administered in 3 divided doses. No organism was isolated in 9 of the 46 patients. Streptococcus pneumoniae was isolated in 43% and Haemophilus influenzae in 27% of the remainder. A bacteriologic cure was achieved in 97% of cases with culturable organisms. The 1 treatment failure was due to a cefaclor-resistant strain of H. influenzae. The medication was well tolerated with the exception of 1 case of eosinophilia that was possibly drug related. Cefaclor given 3 times a day in an effective program for the treatment of otitis media.