Peptide sweeteners. 5. Side chain homologs relating zwitterionic and trifluoroacetylated amino acid anilide and dipeptide sweeteners
- 1 April 1982
- journal article
- research article
- Published by American Chemical Society (ACS) in Journal of Medicinal Chemistry
- Vol. 25 (4) , 397-402
- https://doi.org/10.1021/jm00346a013
Abstract
Side-chain homologues of sweet trifluoroacetyl-.alpha.-L-aspartyl-p-cyanoanilide were synthesized and tasted. Removal of the trifluoroacetyl group only changes the potency of sweet taste, not the taste property. These results were compared with the structure-taste relationships of dipeptide sweeteners. An informative discontinuity of taste effect existed with novel aminomalonyl dipeptide derivatives. The results are explained on topochemical grounds.Keywords
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