Efficacy of Second Line Antiepileptic Drugs in the Treatment of Patients with Medically Refractive Complex Partial Seizures
- 1 April 1986
- Vol. 27 (2) , 124-127
- https://doi.org/10.1111/j.1528-1157.1986.tb03514.x
Abstract
The efficacy of second-line antiepileptic drugs (AEDs) was evaluated in the treatment of 66 patients with complex partial seizures who had previously failed first-line AEDs. Methsuximide, valproate, or clorazepate had eliminated seizures in 11% of the patients at the end of the study. However, these good result deteriorated on longer follow-up and were not expected to be permanent. It is recommended that suitable patients with partial epilepsy be referred for surgical evaluation after failing the first-line AEDs, and that second-line AEDs be reserved for nonsurgical candidates.This publication has 9 references indexed in Scilit:
- Medical therapy for intractable complex partial seizuresCleveland Clinic Journal of Medicine, 1984
- Epileptics refractory to anticonvulsantsNeurology, 1984
- Methsuxirnide for complex partial seizuresNeurology, 1983
- Valproic Acid Therapy for Complex Partial SeizuresArchives of Neurology, 1983
- Bilateral Optic Neuropathy With Remission in Young MenArchives of Neurology, 1983
- Epileptic patients who are refractory to anticonvulsant medicationsNeurology, 1982
- Clorazepate therapy for refractory seizuresNeurology, 1981
- Methsuximide for refractory complex partial seizuresNeurology, 1981
- Plasma concentrations of phensludmide, methsuximide, and their metabolites in relation to clinical efficacyNeurology, 1979