S‐100 proteins and microtubules: analysis of the effects of rat brain S‐100 (S‐100b) and ox brain S‐100a0, S‐100a and S‐100b on microtubule assembly‐diassembly (FEBS 2657)
Open Access
- 1 July 1985
- journal article
- research article
- Published by Wiley in FEBS Letters
- Vol. 186 (1) , 65-69
- https://doi.org/10.1016/0014-5793(85)81340-5
Abstract
Rat brain S-100 (S-100b) and ox brain S-100a0, S-100a and S-100b have been tested for their ability to control the assembly and disassembly of brain microtubule proteins in the presence of either Ca2+ or Zn2+, in vitro. In the presence of Ca2+, single S-100 isoforms have similar, if not identical, effects, i.e. they inhibit assembly and promote disassembly. In the presence of Zn2+ from 0.1 to 1 mM (free concentration), rat S-100 and ox S-100a and S-100b inhibit assembly, while S-100a0 is without effect. These data are briefly discussed in relation to the cellular localization of single S-100 isoforms in the brain.Keywords
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