THE ADRENALS AND SUSCEPTIBILITY TO TRANSPLANTED LEUKEMIA OF RATS

24 December 1943

journal article
research article
Published by American Association for the Advancement of Science (AAAS) in Science

Vol. 98 (2556) , 568
https://doi.org/10.1126/science.98.2556.568

Abstract

90.3% of middle-aged rats and 100% of young rats developed leukemia when adrenalectomized and inoculated later with lymphatic leukemia. In contrast, only 46.9% of intact middle-aged rats, and 96.5% of intact young rats were affected. If young rats were protected with homologous defibrinated blood, only 33.9% of intact animals developed leukemia, whereas adrenalectomy markedly raised the percentage.