Reactivity of Serologic Tests for the Detection of Antibody Specific to Cytomegalovirus: II. Latex Agglutination and Enzyme-Linked Immunosorbent Assay
Open Access
- 1 September 1986
- journal article
- research article
- Published by Oxford University Press (OUP) in American Journal of Clinical Pathology
- Vol. 86 (3) , 354-356
- https://doi.org/10.1093/ajcp/86.3.354
Abstract
Two hundred seven sera were assayed for antibody-specific for cytomegalovirus (CMV) by two enzyme immunoassays (EIAs; Bioenzabody®, Litton Bionetics, and Abbott CMV Total Antibody EIA®, Abbott Laboratories) and latex agglutination (LA; CMVScan®, Hynson, Westcott and Dunning). The overall accuracy of the LA, Litton EIA, and Abbott EIA was 95.8%, 86.2%, and 88.6%, respectively. Although the Abbott EIA had a sensitivity of 98.8%, the specificity was only 35.5%. The positive predictive values of the LA, Litton EIA, and Abbott EIA were 99.4%, 95.9%, and 88.9%, respectively, while the negative predictive values of each of these tests were 81.1%, 56.2%, and 84.6%, respectively.Keywords
This publication has 2 references indexed in Scilit:
- Detection of cytomegalovirus antibody with latex agglutinationJournal of Clinical Microbiology, 1985
- Transfusion‐acquired cytomegalovirus infection in cardiac surgery patientsJournal of Medical Virology, 1985