Antisense phosphorothioate oligodeoxynucleotides: introductory concepts and possible molecular mechanisms of toxicity
- 31 December 1995
- journal article
- review article
- Published by Elsevier in Toxicology Letters
- Vol. 82-83, 419-424
- https://doi.org/10.1016/0378-4274(95)03571-0
Abstract
No abstract availableKeywords
This publication has 13 references indexed in Scilit:
- Brief overview of control of genetic expression by antisense oligonucleotides and in vivo applicationsMolecular Neurobiology, 1995
- Review of in vivo pharmacokinetics and toxicology of phosphorothioate oligonucleotidesJournal of Clinical Laboratory Analysis, 1995
- Gene-Mimetic Substances: Drugs Designed to Intervene in Gene ExpressionPublished by Elsevier ,1994
- Antisense Oligonucleotides as Therapeutic Agents—Is the Bullet Really Magical?Science, 1993
- Current concepts in antisense drug designJournal of Medicinal Chemistry, 1993
- Intracellular disposition and metabolism of fluorescently-labled unmodified and modified oligouncleotides microijjected into mammalian cellsNucleic Acids Research, 1993
- Cellular uptake and intracellular fate of antisense oligonucleotidesTrends in Cell Biology, 1992
- Mechansism of cellular uptake of modified oligodeoxynucleotides containing methylphosphonate linkagesNucleic Acids Research, 1991
- Antisense oligonucleotides: a new therapeutic principleChemical Reviews, 1990
- Comparative inhibition of chloramphenicol acetyltransferase gene expression by antisense oligonucleotide analogues having alkyl phosphotriester, methylphosphonate and phosphorothioate linkagesNucleic Acids Research, 1987