Versatile, Diastereoselective Additions of Silyl Ketene Acetals, Allyl Tributylstannane, and Me3SiCN to N-Acyl Pyrazolines: Asymmetric Synthesis of Densely Functionalized Pyrazolidines
- 1 December 2000
- journal article
- letter
- Published by American Chemical Society (ACS) in Organic Letters
- Vol. 2 (26) , 4265-4267
- https://doi.org/10.1021/ol006873f
Abstract
We report the diastereoselective addition of a wide range of nucleophiles to chiral pyrazolines to provide facile access to a range of useful densely functionalized building blocks for asymmetric synthesis. Coupled with the asymmetric cycloaddition reaction of Me3SiCHN2 to chiral acrylates, access to these chiral heterocycles is considerably expanded.Keywords
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