Familial Pulmonary Hypertension

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Abstract
IN a small fraction of patients with pulmonary hypertension detailed clinical, hemodynamic and histologic examinations do not uncover a specific cause, and such patients are considered to suffer from primary pulmonary hypertension. Several observers have suggested that a familial form of this disease exists,1 2 3 4 5 6 7 8 9 and it is the purpose of this report to describe a kindred in which 5 members in three generations had primary pulmonary hypertension. The probable mechanism of genetic transmission is discussed, and the published evidence for the existence of familial pulmonary hypertension is reviewed.Clinical DescriptionsCase 1. R.H. (03–93–62), the propositus (Fig. 1, III-21), was . . .