The gene for Darier's disease maps to chromosome 12q23–q24.1

Open Access
Publisher Website
Google Scholar
Abstract
Darler's disease is a rare autosomal dominant skin disorder in which there is abnormal adhesion between keratlnocytes. It appears to be associated with an Increased prevalence of neuropsychiatrlc disorders including mental retardation and epilepsy. In addition we have previously reported a family in which major affective disorder cosegregates with Darier's disease. In the present study we have localized the gene for Darier's disease to chromosome 12q23–q24.1 by linkage analysis in five British pedigrees. We obtained a maximum two point lod score of 4.29 with marker D12S84 at zero recombination fraction. All five families showed evidence of linkage between the disease gene and markers In this region. Subsequent identification of the Darier's disease gene will provide Insights into normal mechanisms of cell adhesion and may be of importance in the genetic Investigation of neuropsychiatric disorders as well as elucidating the pathogenesls of Darier's disease itself.