Various phenotypes of diabetes mellitus as ultimate outcome of acutely developed diabetic state induced by viral infection.

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Abstract
For 4 to 8 yr, 3 diabetic patients in whom the onset of diabetes seemed to be closely related to the well-documented Epstein-Barr virus infection (Case 1) or Coxsackie virus B4 infection (Case 2,3) were followed up. Although all developed acute ketosis-prone diabetes in the convalescent stage of the viral infections, the subsequent clinical courses were quite different from each other. Case 1 has remained consistently insulin-dependent and associated with positive islet cell antibody, gastric parietal cell antibody, thyroglobulin hemagglutinating antibody and thyroidal microsomal hemagglutinating antibody. Case 2 restored normal glucose tolerance. Case 3 has developed noninsulin-dependent diabetes mellitus after a 6 yr interval. Thus, viruses could be responsible for the occurrence of different types of diabetes.

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