Synthesis of Two Novel Cyclic Biphenyl Ether Analogs of an Inhibitor of HCV NS3 Protease

8 June 1999

journal article
letter
Published by Georg Thieme Verlag KG in Synlett

Vol. 1999 (Sup. 1) , 1000-1002
https://doi.org/10.1055/s-1999-3119

Abstract

The synthesis of two cyclic ether analogs of a tetrapeptide inhibitor of the hepatitis C virus NS3 protease has been carried out using intramolecular nucleophilic aromatic substitution (S_NAr) reactions of ruthenium π-aryl complexes of pre-assembled tripeptides.

Keywords

HEPATITIS C
NS3 PROTEASE
ENZYME INHIBITOR
CYCLIC ETHER
NUCLEOPHILIC AROMATIC SUBSTITUTION

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