Diagnosis of carcinoma of the pancreas by assay of immunosuppressive acidic protein.

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Abstract
To establish a procedure for the screening of pancreatic cancer, the serum level of immunosuppressive acidic protein (IAP) was assayed in patients with malignant and benign pancreatic diseases and compared with the serum level of carcinoembryonic antigen (CEA). In 96% of 46 pancreatic cancer patients, the serum IAP level averaged 928 .mu.g/ml; while 500 .mu.g/ml or below was obtained as the normal value in 211 healthy adults. The serum IAP level may be elevated in the presence of nonmalignant, inflammatory pancreatic diseases. For the differential diagnosis of pancreatic cancer, other laboratory data need to be taken into account. The serum IAP level was correlated with the progression of pancreatic cancer and may provide a means to determine whether tumor resection of pancreatic cancer and may provide a means to determine whether tumor resection was radical or admitting of recurrence. The serum IAP level in samples obtained from different sites of the portal system did not reflect tumor location in patients with pancreatic cancer.

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