Functional DNAzymes Organized into Two-Dimensional Arrays
- 24 June 2006
- journal article
- letter
- Published by American Chemical Society (ACS) in Nano Letters
- Vol. 6 (7) , 1505-1507
- https://doi.org/10.1021/nl0609955
Abstract
DNAzymes are catalytically active DNA molecules, which have previously been described in solution. Here, we organize these molecules into a series of two-dimensional (2D) arrays using a periodic arrangement of DNA structures based on the DNA double crossover motif. We demonstrate by means of atomic force microscopy that the DNAzymes are organized according to the design and that they retain their activity when attached in linear strings within the context of the 2D array.Keywords
This publication has 22 references indexed in Scilit:
- Folding DNA to create nanoscale shapes and patternsNature, 2006
- Six-Helix Bundles Designed from DNANano Letters, 2005
- DNA in a material worldNature, 2003
- In Vitro Selection of Kinase and Ligase DeoxyribozymesMethods, 2001
- Mechanism and Utility of an RNA-Cleaving DNA EnzymeBiochemistry, 1998
- DNA ribonucleases that are active against intracellular hepatitis B viral RNA targetsHepatology, 1998
- In vitro selection of self-cleaving DNAsChemistry & Biology, 1996
- A DNA metalloenzyme with DNA ligase activityNature, 1995
- DNA double-crossover moleculesBiochemistry, 1993
- Nucleic acid junctions and latticesJournal of Theoretical Biology, 1982