Effect of Doxepin on Basal Gastric Acid and Salivary Secretion in Patients with Duodenal Ulcer

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Abstract
We compared the effect of 50- or 100-mg doses of oral doxepin or a placebo on basal gastric secretion, salivary flow, and pulse rate in seven asymtomatic patients with chronic duodenal ulcer disease. Acid secretion and salivary flow were measured for four 1-hour periods beginning at 3.5, 5.5, 7.5, and 9.5 hours after medication, with plasma sampling for measurement of doxepin at the midpoint of each collection period. Compared to placebo, the 50- and 100-mg doses of doxepin reduced mean basal acid output by 46% and 37%, respectively. There was no significant difference in the effect of the 50- or 100-mg dose on acid secretion even though mean plasma concentrations of doxepin were higher with the 100-mg than with the 50-mg dose (p < 0.01). Salivary flow was reduded by 62% and 84% with the 50- and 100-mg doses, respectively, whereas doxepin had no effect on mean pulse rate.