Identification of Quorum-Sensing-Regulated Genes of Burkholderia cepacia
Open Access
- 1 November 2003
- journal article
- Published by American Society for Microbiology in Journal of Bacteriology
- Vol. 185 (21) , 6456-6462
- https://doi.org/10.1128/jb.185.21.6456-6462.2003
Abstract
Quorum sensing is a regulatory mechanism (operating in response to cell density) which in gram-negative bacteria usually involves the production of N -acyl homoserine lactones (HSL). Quorum sensing in Burkholderia cepacia has been associated with the regulation of expression of extracellular proteins and siderophores and also with the regulation of swarming and biofilm formation. In the present study, several quorum-sensing-controlled gene promoters of B. cepacia ATCC 25416 were identified and characterized. A total of 28 putative gene promoters show CepR-C 8 -HSL-dependent expression, suggesting that quorum sensing in B. cepacia is a global regulatory system.Keywords
This publication has 50 references indexed in Scilit:
- Differential Expression of Two Catechol 1,2-Dioxygenases in Burkholderia sp. Strain TH2Journal of Bacteriology, 2002
- Global Genomic Analysis of AlgU (σ E )-Dependent Promoters (Sigmulon) in Pseudomonas aeruginosa and Implications for Inflammatory Processes in Cystic FibrosisJournal of Bacteriology, 2002
- Defining the Bacillus subtilis σW regulon: a comparative analysis of promoter consensus search, run-off transcription/macroarray analysis (ROMA), and transcriptional profiling approachesJournal of Molecular Biology, 2002
- Regulation of Gene Expression by Cell-to-Cell Communication: Acyl-Homoserine Lactone Quorum SensingAnnual Review of Genetics, 2001
- Quorum-sensing in Gram-negative bacteriaFEMS Microbiology Reviews, 2001
- Synthesis of Multiple N-Acylhomoserine Lactones is Wide-spread Among the Members of the Burkholderia cepacia ComplexSystematic and Applied Microbiology, 2001
- Identification and cell cycle control of a novel pilus system in Caulobacter crescentusThe EMBO Journal, 2000
- Characterization of Mip proteins ofLegionella pneumophilaFEMS Microbiology Letters, 1994
- Mip protein of Legionella pneumophila exhibits peptidyl‐prolyl‐cis/trans isomerase (PPIase) activityMolecular Microbiology, 1992
- Pseudomonas cepacia infection in cystic fibrosis: An emerging problemThe Journal of Pediatrics, 1984