Erythropoietic Factor in Kidney Tissue of Anemic Dogs.

Publisher Website
Google Scholar
Abstract
Attempt to demonstrate erythropoietic activity in kidney homogenates of anemic dogs was made. "Anemic" kidney homogenates induced in injected starved rats a higher Fe59 uptake (15.0 [plus or minus] 7.2) than normal kidney (9.1 [plus or minus] 4.5), "anemic" liver (10.6 [plus or minus] 4.4.) and "anemic" spleen (9.9 [plus or minus] 7.9). Increased uptake was not due to lowering of the plasma Fe level of the recipient rats by foreign proteins injected. These results suggest the importance of developing a method for concentrating and purifying the erythropoietic activity of tissue homogenates to help clarify the role of the kidney in erythropoietin production.