Antihypertensive 5,6-diarylpyridazin-3-ones

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Abstract
The synthesis of a series of 5,6-diarylpyridazinones is described. Some nembers of this series display an antihypertensive effect in the spontaneously hypertensive rat (SHR) model and the deoxycorticosteroid model of hypertension. The most potent compounds in the series have halogen substituents on the 5,6-diphenyl rings, a .beta.-substituted alkyl group at the 2 position of the ring and an acetyl or cyano substituent at the 4 position.

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